How Rheumatoid Arthritis Affects the Whole Body
Adults With Congenital Heart Disease Faced Higher Risk Of Abnormal Heart Rhythms
Almost 1 in 5 adults with congenital heart disease living in Israel had or developed an abnormal heart rhythm/arrhythmia during a five-year study, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.
The study of more than 11,000 adults with congenital heart disease between 2007 and 2011 found that those who developed forms of abnormal heart rhythms had an increased risk for hospitalization and twice the risk of early death compared to study participants who did not have an irregular heart rhythm.
"Our findings highlight the need for ongoing, lifelong, clinical follow-up for people with congenital heart disease," said lead study author Nili Schamroth-Pravda, MBBCh, a cardiologist at the Rabin Medical Center in Petah Tikva, Israel. "With the improvement of medical and surgical techniques, the number of patients with congenital heart disease reaching adulthood is increasing, as well as the complications associated with these heart conditions.
"The health care system should be aware of the unfavorable effects of arrhythmias in this increasing population and the consequent increase in both primary care visits and hospitalizations," Schamroth-Pravda said.
The analysis found:
Researchers note that surgical scar tissue in the heart, even years after repairing a congenital heart defect, may increase the risk for abnormal heart rhythms later in life. The challenge to clinicians is to achieve early detection and early management of arrhythmias that could pose life-threatening health risks. Learning more about the frequency of these different types of arrhythmias and how they progress among adults with congenital heart disease can help improve treatment for these patients and prevent complications and hospitalizations.
The study is among the first to analyze health care use in association with arrhythmias among adults with congenital heart disease.
"Our study suggests that the development of arrythmias is a critical point in the life of adult patients with congenital heart disease and this has a profound impact on the health care system providing care for these patients," Schamroth-Pravda said.
"Our study is from large, real-world data and gives insights into a population that is under-studied," she said. "Congenital heart disease can be varied with people having simple or complex heart lesions, however, they all carry some risk of an abnormal heart rhythm in later life and should be assessed individually and monitored on a regular basis."
According to the 2024 Heart Disease and Stroke Statistics: A Report of U.S. And Global Data From the American Heart Association, an estimated 13.3 million people globally were living with congenital heart diseases in 2019. Occurrences increased by 28% between 1990 and 2019, driven largely by increases in the number of adolescents, younger adults and middle-aged adults living with congenital heart diseases.
Study background and details:
One of the limitations of the findings is that it is based solely on patients in Israel. How these findings might translate to adults with congenital heart disease in the United States or elsewhere is unclear.
Affairs Of The Heart
Russell Cothren, University Relations Morten Jensen
"One percent of all live births have some type of heart defect," explains Morten Jensen, an associate professor of biomedical engineering at the U of A who specializes in developing innovative medical devices and experimental cardiovascular surgery. "That's nothing to be alarmed about because you don't see one out of every 100 live births needing surgery. The majority of people who have small defects never need to worry about it."
A case in point: Jensen himself has a leaking pulmonary valve, discovered by a colleague who assured him that 60% of adults suffer from the same condition. Which invites the question: if more than half of all adults have a leaky valve, is it really a defect or is it supposed to be like that?
Ultimately, Jensen says, "Many things can go wrong in the development process of the heart, and it's one of the imperfect wonders of nature that creates something that is so remarkable. It's a design that took 5 billion years to develop."
To talk to Jensen is to be immersed in the mystery and wonder of the human heart. Its leaky valves. Its coronary bifurcations and blockages. Its left ventricle muscles creating five Newtons of force every time they open and close the mitral valve (which he simulates by grabbing two 500ml plastic bottles and banging them down).
Oh, and the word mitral? It means "shaped like a mitre" in Latin, which is the pointed hat the pope wears.
When Jensen says of the heart, "it's simple, beautiful, but incredibly complex," it's clear his fascination stems from a deep understanding of its function and mechanics.
Jensen came to the university in 2015 as an Arkansas Research Alliance Scholar and is now the principal investigator at the Cardiovascular Biomechanics Laboratory. Unfortunately, he has his work cut out for him: cardiovascular disease is the number one killer worldwide while Arkansas, and its surrounding states have the highest death rates from cardiovascular disease in the United States (the others are nearby Oklahoma, Mississippi, Louisiana and Alabama).
The CBLab brings engineers and clinicians together to address conditions such as heart attack, stroke, heart failure and congenital heart disease while creating novel approaches in the prevention, diagnosis and treatment of cardiovascular disease.
A Transformative InternshipJensen got into the field almost by accident. When he was a computer and electrical engineering student in Denmark, where he was born, he was required to do a one-semester internship on a research or industry-related project. He did this with the Bioengineering Department of Aarhus University Hospital, where he witnessed heart surgeries on humans, including a heart transplant. The experience set him on an entirely new course.
"I thought it was extremely fascinating with the heart being a pump," Jensen explained. "You could look at the heart as a mechanical device, adding pressure to fluids and the fluids flowing into the blood vessels."
He also witnessed researchers doing experiments on large animals.
"I saw what the researchers were able to do on large animals in the basement of that hospital — making measurements on the hearts, both electrical and force measurements, flow measurements and pressure measurements. And that's why I became interested in this work."
One of the people working in the basement was J. Michael Hasenkam, who was part of the team that invented the Transcatheter Aortic Valve Implantation, or TAVI, a revolutionary procedure that enables surgeons to implant a new heart valve with a catheter by going through a blood vessel in the armpit or groin. Ten years later, after Jensen had earned a master's degree in biomedical engineering at the Georgia Institute of Technology, Hasenkam would become one of Jensen's Ph.D. Advisers back at Aarhus.
In 2015, Jensen became just the third engineer in Denmark since 1479 to obtain the prestigious Doctor of Medical Science degree, which is officially a higher doctorate, ranking above a Ph.D.
The Angle of BifurcationSince he saw that first heart transplant, Jensen has helped contribute intellectual property to nine patent applications. This has included development of lifelike artificial tissues to aid medical students in their training, spoons to assist with the removal of bladder stones on companion animals and a heart valve created from animal tissues that can be implanted in humans.
Kaitlyn Elmer, a Ph.D. Student in biomedical engineering from Springfield, Missouri, conducts research in Jensen's lab. Elmer and Jensen are specifically focused on arterial blockages at a coronary bifurcation. This is where a major artery splits into smaller blood vessels. Elmer noted that "Twenty percent of plaque blockages are actually in a bifurcation. And since it's branching, it's just a weird shape and really difficult for physicians to use conventional methods to treat those."
She said that normal methods employ a balloon to expand a stent that props the vessel open. These constructs are usually cylindrically shaped, but the bifurcation typically is not. So, she and Jensen are working with cardiologists to create a stent that is designed to fit in the bifurcation, which can have a range of angles. This has required development of a computer program to measure the angles of these bifurcations, so that they can create better designed balloons and stents. Prototypes are then created and tested in ballistic gel models to see how the stent's shape changes when expanded.
The project is funded by the American Heart Association, and the technology is promising enough that they applied for two patents through the U of A's Technology Ventures: one for the software program that measures the angle of bifurcation and another for the actual devices.
Vascugenix, a company based in Little Rock specializing in medical devices for interventional cardiology surgery, has signed an option agreement with Tech Ventures that would pave the way for licensing pending further development.
Noah Ascher, CEO of Vascugenix, said, "There is a clear need for a solution in the treatment of bifurcation lesions, and it is our company's vision to work with Dr. Jensen to develop, manufacture and deliver a comprehensive stent system for addressing this need."
Elmer confirmed that "Morten is really good at the industry and clinical partnerships. So I've been able to work with a clinician who has a lot of experience, Dr. [Barry] Uretsky. And Morten's helped coordinate things with Vascugenix. So, I've learned a lot about the industry and business side of things."
A Better Way to Detect Internal BleedingJensen is also the principal investigator on a recent $1.9 million award from the Department of Defense to develop a wearable device for the early detection and monitoring of internal or external bleeding.
Hemorrhagic shock is currently the leading cause of preventable death in casualty care settings. Existing methods often fail to detect blood loss until the onset of shock, which can be too late for some patients. This makes early detection and management of bleeding-related conditions critical to improving survival rates.
Jensen is working with a multi-disciplinary team to design a mobile device that can detect blood pressure waveforms, which correlate with the volume of blood within the blood vessels, the "intravascular volume," and can be used to determine if blood volume is falling due to hemorrhaging. This will enable first responders and hospital staff to get more accurate readings earlier and respond with better timed and more precisely calibrated care.
Jensen will be joined by Jingxian Wu, a U of A professor of electrical engineering, and Robert Saunders, an associate department head of electrical engineering and computer science. Hanna Jensen, an assistant professor in the Department of Surgery at the University of Arkansas for Medical Sciences and course director of the school's cardiovascular module, will oversee the translational and clinical phases of the project.
Ultimately, their goal is to develop a device that is less than an inch square and sells for less than $100. It would have a catheter that connects to a vein as well as a port to which an IV bag could be connected.
Collaboration Is KeySaunders, who teaches a senior design class in the College of Engineering, has worked with Jensen on a range of projects. How many? "Wow, that's a long list," Saunders laughs before rattling off a few: "Heated pulse oximeters for people who have bad circulation. Wheelchair monitors for disabled people. An Ohm device to determine whether or not an artificial knee has appropriate motion."
Saunders said of Jensen, "He's a great part of the team. Everybody is really dedicated to the project they're working on. They're dedicated to the students around them."
Collaboration is clearly key to Jensen's success, from witnessing those teams in the Aarhus basement, to all the adjoining names on his patent applications, to his recent research projects.
In fact, one of his closest collaborators is his wife, Hanna, who is an M.D. She said she knew Jensen professionally before knowing him personally. Their research topics were so closely related that they kept presenting at the same sessions of the same conferences: her on the medical side, him on the engineering.
"I distinctly remember Morten walking up to me after one of my first presentations and telling me he could write a program to automatically count the number of activated leukocytes on an intravital microscope video clip — something I had spent painstaking months doing manually alone in a dark room as a medical student," Hanna Jensen said. "I always joke that it was the moment I knew I'd marry him!"
They've since collaborated on a number of projects, including the current DOD grant, a vector flow imaging study on pediatric patients to create detailed images of the internal structure and blood flow of babies' hearts, and two children, Matilda and Lukas.
"We figured out we can constantly learn from each other and fill gaps on the continuum of biomedical research," Hanna explained, "and we respect each other's areas of expertise, so we rarely clash on professional topics. We also have distinct roles that work well for us in professional and personal life. Morten is the idea generator, and I am the organizer. We both love to be connected and plugged into our professional communities, and it's been so rewarding to find collaborators on both the medicine and engineering side — we are both at our best as team players. Plus, when a big deadline is looming, we can gear the entire family schedule towards making it happen."
CodaIn a recent conversation, Jensen offered a quick tour of the heart, showing how blood comes in from the lungs through the left atrium, passes through the mitral valve, which prevents it from flowing backwards, then enters the left ventricle and pushes on to the aorta. From there it circulates through the body until it finally returns to the heart through the right ventricle and is sent back to the lungs for more oxygen.
He concludes: "So it's pretty neat, the way it works."
He's just got a few more things to fix.
Months After Receiving Treatment At Mayo For Congenital Heart Defect, Bronny James Declares For NBA Draft
ROCHESTER — Six months after receiving medical care at Mayo Clinic in Rochester for a congenital heart defect that caused his heart to go into cardiac arrest, Bronny James, son of Los Angeles Lakers superstar Lebron James, announced on Friday, April 5, 2024 that he's entering the NBA draft and the NCAA transfer portal.
His father has long indicated that he wants to play in the NBA with his son before retiring from the game. By declaring both for the draft and transfer portal, the 19-year-old Bronny is keeping his options open.
If he doesn't get picked in the NBA draft, Bronny can join another college team through the NCAA transfer portal.
Bronny James, 19, is a freshman guard at University of Southern California.
"I've had a year with some ups and downs but all added to growth for me as a man, student and athlete," Bronny James wrote on social media.
The oldest of LeBron James's three children, Bronny James suffered a cardiac arrest last July 24 during a workout at USC. Bronny James spent time at Mayo Clinic in September where he received treatment for his heart. He was accompanied by his dad, who was seen around town in Rochester and used the time to workout at Rochester Lourdes High School.
LeBron, a four-time NBA Most Valuable Player and the league's all-time leading scorer, gave a heart-warming shoutout to the Catholic school and its staff for opening up its gym and weight room during his stay in Rochester. He also electrified the student body and staff with an appearance in the Lourdes auditorium.
"HUGE s/o Lourdes High School in Rochester, MN for this week's long hospitality, love and support," LeBron James wrote on social media. "To the faculty, teachers, coaches, (principal), students you guys absolute ROCK!!!!"
A month after his cardiac arrest, a statement issued by the LeBron James Family Foundation expressed confidence in Bronny's full recovery and his return to basketball.
"It is an anatomically and functionally significant Congenital Heart Defect which can and will be treated," the statement said.
Bronny was seen by doctors at Mayo Clinic and Atlantic Health-Morristown Medical Center in New Jersey.
Bronny averaged 4.8 points and 2.8 rebounds while starting six of 25 games for the Trojans. If the duo ended up on the same team, it would be the first father-son tandem in the league's history.
The prospect will intrigue NBA teams. LeBron's contract allows him the option to sign with another team next season. That two-for-one prospect could make Bronny a hot pick in the NBA draft.
Matthew Stolle has been a Post Bulletin reporter since 2000 and covered many of the beats that make up a newsroom. In his first several years, he covered K-12 education and higher education in Rochester before shifting to politics. He has also been a features writer. Today, Matt jumps from beat to beat, depending on what his editor and the Rochester area are producing in terms of news. Readers can reach Matthew at 507-281-7415 or mstolle@postbulletin.Com.
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